Which skin disease is noted for being caused by a disorder of keratinization?

Ichthyosis is indeed noted for being caused by a disorder of keratinization. This skin condition is characterized by dry, scaly skin resulting from the abnormal development and shedding of keratinocytes, the cells responsible for producing keratin, a key protein in the outer layer of the skin. In individuals with ichthyosis, there is often a disruption in the natural shedding process, leading to an accumulation of dead skin cells on the surface. This accumulation can give the skin a thickened, scaly appearance.

This relationship between ichthyosis and keratinization disorders highlights the importance of keratin in maintaining skin health and function. The abnormality in keratinization is a hallmark of ichthyosis, differentiating it from other skin conditions that may have distinct causes or mechanisms, such as acne, melanoma, or psoriasis. While psoriasis also involves a rapid turnover of skin cells and can be related to inflammation, its primary pathophysiology is distinct from the keratinization issues found in ichthyosis.